Relatively little long-distance multi-state traffic currently uses N-35. However, highway improvements in Nebraska, Iowa, Wisconsin, Illinois and Minnesota could potentially increase the attractiveness of N-35 as a corridor used by longer-distance traffic. These improvements include:
- Four-lane improvement of US 20 from Chicago to Sioux City
- Four-lane improvement of Highway 60 from Sioux City to Minneapolis
- Completion of the Vermillion-Newcastle Bridge across the Missouri River
- Four-lane improvement of US 151 between Dubuque and Madison, Wisconsin
The planned highway improvements in Nebraska and the highway changes planned in the multi-state network may provide the impetus to cause traffic to funnel from Minnesota, Wisconsin, Illinois and Northern Iowa through the Northeast Nebraska Region and then on to Western Nebraska and other points west. The only missing highway link is the section between Norfolk and Sioux City.